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Adaptive designs for subpopulation analysis optimizing utility functions
If the response to treatment depends on genetic biomarkers, it is important to identify predictive biomarkers that define (sub-)populations where the treatment has a positive benefit risk balance. One approach to determine relevant subpopulations are subgroup analyses where the treatment effect is e...
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| Pubblicato in: | Biom J |
|---|---|
| Autori principali: | , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Blackwell Publishing Ltd
2015
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4314682/ https://ncbi.nlm.nih.gov/pubmed/25399844 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/bimj.201300257 |
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