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Structural and Mechanistic Insights into C−S Bond Formation in Gliotoxin
Glutathione‐S‐transferases (GSTs) usually detoxify xenobiotics. The human pathogenic fungus Aspergillus fumigatus however uses the exceptional GST GliG to incorporate two sulfur atoms into its virulence factor gliotoxin. Because these sulfurs are essential for biological activity, glutathionylation...
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| Publicado no: | Angew Chem Int Ed Engl |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8251611/ https://ncbi.nlm.nih.gov/pubmed/33909314 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.202104372 |
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