Structural and Mechanistic Insights into C−S Bond Formation in Gliotoxin

Glutathione‐S‐transferases (GSTs) usually detoxify xenobiotics. The human pathogenic fungus Aspergillus fumigatus however uses the exceptional GST GliG to incorporate two sulfur atoms into its virulence factor gliotoxin. Because these sulfurs are essential for biological activity, glutathionylation...

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Detalhes bibliográficos
Publicado no:Angew Chem Int Ed Engl
Main Authors: Scherlach, Kirstin, Kuttenlochner, Wolfgang, Scharf, Daniel H., Brakhage, Axel A., Hertweck, Christian, Groll, Michael, Huber, Eva M.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2021
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8251611/
https://ncbi.nlm.nih.gov/pubmed/33909314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.202104372
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