N‐Heterocyclization in Gliotoxin Biosynthesis is Catalyzed by a Distinct Cytochrome P450 Monooxygenase

Gliotoxin and related epidithiodiketopiperazines (ETP) from diverse fungi feature highly functionalized hydroindole scaffolds with an array of medicinally and ecologically relevant activities. Mutation analysis, heterologous reconstitution, and biotransformation experiments revealed that a cytochrom...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Chembiochem
Päätekijät: Scharf, Daniel H., Chankhamjon, Pranatchareeya, Scherlach, Kirstin, Dworschak, Jan, Heinekamp, Thorsten, Roth, Martin, Brakhage, Axel A., Hertweck, Christian
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: John Wiley and Sons Inc. 2020
Aiheet:
Communications
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC7891397/
https://ncbi.nlm.nih.gov/pubmed/32835438
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.202000550
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