N‐Heterocyclization in Gliotoxin Biosynthesis is Catalyzed by a Distinct Cytochrome P450 Monooxygenase

Gliotoxin and related epidithiodiketopiperazines (ETP) from diverse fungi feature highly functionalized hydroindole scaffolds with an array of medicinally and ecologically relevant activities. Mutation analysis, heterologous reconstitution, and biotransformation experiments revealed that a cytochrom...

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Detaylı Bibliyografya
Yayımlandı:Chembiochem
Asıl Yazarlar: Scharf, Daniel H., Chankhamjon, Pranatchareeya, Scherlach, Kirstin, Dworschak, Jan, Heinekamp, Thorsten, Roth, Martin, Brakhage, Axel A., Hertweck, Christian
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: John Wiley and Sons Inc. 2020
Konular:
Communications
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7891397/
https://ncbi.nlm.nih.gov/pubmed/32835438
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.202000550
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