N‐Heterocyclization in Gliotoxin Biosynthesis is Catalyzed by a Distinct Cytochrome P450 Monooxygenase

Gliotoxin and related epidithiodiketopiperazines (ETP) from diverse fungi feature highly functionalized hydroindole scaffolds with an array of medicinally and ecologically relevant activities. Mutation analysis, heterologous reconstitution, and biotransformation experiments revealed that a cytochrom...

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Bibliografiske detaljer
Udgivet i:Chembiochem
Main Authors: Scharf, Daniel H., Chankhamjon, Pranatchareeya, Scherlach, Kirstin, Dworschak, Jan, Heinekamp, Thorsten, Roth, Martin, Brakhage, Axel A., Hertweck, Christian
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2020
Fag:
Communications
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7891397/
https://ncbi.nlm.nih.gov/pubmed/32835438
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.202000550
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