Structural, mechanistic and functional insight into gliotoxin bis-thiomethylation in Aspergillus fumigatus

Gliotoxin is an epipolythiodioxopiperazine (ETP) class toxin, contains a disulfide bridge that mediates its toxic effects via redox cycling and is produced by the opportunistic fungal pathogen Aspergillus fumigatus. Self-resistance against gliotoxin is effected by the gliotoxin oxidase GliT, and att...

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Detalhes bibliográficos
Publicado no:Open Biol
Main Authors: Dolan, Stephen K., Bock, Tobias, Hering, Vanessa, Owens, Rebecca A., Jones, Gary W., Blankenfeldt, Wulf, Doyle, Sean
Formato: Artigo
Idioma:Inglês
Publicado em: The Royal Society 2017
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5356443/
https://ncbi.nlm.nih.gov/pubmed/28179499
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rsob.160292
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