Towards understanding the gliotoxin detoxification mechanism: in vivo thiomethylation protects yeast from gliotoxin cytotoxicity

Gliotoxin (GT) is a mycotoxin produced by some species of ascomycete fungi including the opportunistic human pathogen Aspergillus fumigatus. In order to produce GT the host organism needs to have evolved a self-protection mechanism. GT contains a redox-cycling disulfide bridge that is important in m...

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Detalhes bibliográficos
Publicado no:Microb Cell
Main Authors: Smith, Elizabeth B., Dolan, Stephen K., Fitzpatrick, David A., Doyle, Sean, Jones, Gary W.
Formato: Artigo
Idioma:Inglês
Publicado em: Shared Science Publishers OG 2016
Assuntos:
Microbiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5349022/
https://ncbi.nlm.nih.gov/pubmed/28357342
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15698/mic2016.03.485
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