The Aspergillus fumigatus Protein GliK Protects against Oxidative Stress and Is Essential for Gliotoxin Biosynthesis

The function of a number of genes in the gliotoxin biosynthetic cluster (gli) in Aspergillus fumigatus remains unknown. Here, we demonstrate that gliK deletion from two strains of A. fumigatus completely abolished gliotoxin biosynthesis. Furthermore, exogenous H(2)O(2) (1 mM), but not gliotoxin, sig...

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Detalhes bibliográficos
Main Authors: Gallagher, Lorna, Owens, Rebecca A., Dolan, Stephen K., O'Keeffe, Grainne, Schrettl, Markus, Kavanagh, Kevin, Jones, Gary W., Doyle, Sean
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2012
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3485926/
https://ncbi.nlm.nih.gov/pubmed/22903976
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/EC.00113-12
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