Inhibition of mTOR by rapamycin does not improve hypoxic pulmonary hypertension-induced right heart failure in old mice

Inhibition of the mammalian target of rapamycin (mTOR) by rapamycin attenuates heart failure (HF) and age-associated changes in left ventricular (LV) function. Rapamycin has also been suggested as a therapy for pulmonary hypertension (PH) and concomitant right heart failure (PH-RHF) based on reports...

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Veröffentlicht in:Exp Gerontol
Hauptverfasser: McNair, Benjamin D., Schlatter, Jacob A., Cook, Ross F., Yusifova, Musharraf, Bruns, Danielle R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2021
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8248895/
https://ncbi.nlm.nih.gov/pubmed/33971279
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.exger.2021.111395
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