Widespread displacement of DNA‐ and RNA‐binding factors underlies toxicity of arginine‐rich cell‐penetrating peptides

Due to their capability to transport chemicals or proteins into target cells, cell‐penetrating peptides (CPPs) are being developed as therapy delivery tools. However, and despite their interesting properties, arginine‐rich CPPs often show toxicity for reasons that remain poorly understood. Using a (...

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Veröffentlicht in:EMBO J
Hauptverfasser: Lafarga, Vanesa, Sirozh, Oleksandra, Díaz‐López, Irene, Galarreta, Antonio, Hisaoka, Misaru, Zarzuela, Eduardo, Boskovic, Jasminka, Jovanovic, Bogdan, Fernandez‐Leiro, Rafael, Muñoz, Jaime, Stoecklin, Georg, Ventoso, Iván, Fernandez‐Capetillo, Oscar
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2021
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8246256/
https://ncbi.nlm.nih.gov/pubmed/33978236
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.2019103311
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