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Cryo-EM structure of substrate-free E. coli Lon protease provides insights into the dynamics of Lon machinery

Energy-dependent Lon proteases play a key role in cellular regulation by degrading short-lived regulatory proteins and misfolded proteins in the cell. The structure of the catalytically inactive S679A mutant of Escherichia coli LonA protease (EcLon) has been determined by cryo-EM at the resolution o...

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Detalhes bibliográficos
Publicado no:Curr Res Struct Biol
Main Authors: Botos, Istvan, Lountos, George T., Wu, Weimin, Cherry, Scott, Ghirlando, Rodolfo, Kudzhaev, Arsen M., Rotanova, Tatyana V., de Val, Natalia, Tropea, Joseph E., Gustchina, Alla, Wlodawer, Alexander
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8244335/
https://ncbi.nlm.nih.gov/pubmed/34235464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.crstbi.2019.10.001
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