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Structural design of tetravalent T-cell engaging bispecific antibodies: improve developability by engineering disulfide bonds
Since the advances in protein engineering and manufacture, over the last 30 years, antibody-based immunotherapeutic has become a powerful strategy to treat diseases. The T-cell engaging bispecific antibody (BsAb) by combining the Fab binding domain of tumor antigens and Fab or single-chain variable...
Guardat en:
| Publicat a: | J Biol Eng |
|---|---|
| Autors principals: | , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
BioMed Central
2021
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8243740/ https://ncbi.nlm.nih.gov/pubmed/34187511 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13036-021-00272-7 |
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