Increased expression of yes-associated protein/YAP and transcriptional coactivator with PDZ-binding motif/TAZ activates intestinal fibroblasts to promote intestinal obstruction in Crohn's disease

BACKGROUND: Intestinal obstruction caused by intestinal fibrosis is a common and serious complication of Crohn's disease (CD). Intestinal fibroblasts, the main effector cells mediating gastrointestinal fibrosis, are activated during chronic inflammation. However, the mechanism of fibroblast act...

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Detalhes bibliográficos
Publicado no:EBioMedicine
Main Authors: Ou, Weijun, Xu, Weimin, Liu, Fangyuan, Guo, Yuegui, Huang, Zhenyu, Feng, Tienan, Liu, Chen-Ying, Du, Peng
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2021
Assuntos:
Research paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8243379/
https://ncbi.nlm.nih.gov/pubmed/34186485
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2021.103452
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