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Structural basis of DNA synthesis opposite 8-oxoguanine by human PrimPol primase-polymerase
PrimPol is a human DNA polymerase-primase that localizes to mitochondria and nucleus and bypasses the major oxidative lesion 7,8-dihydro-8-oxoguanine (oxoG) via translesion synthesis, in mostly error-free manner. We present structures of PrimPol insertion complexes with a DNA template-primer and cor...
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| Publicat a: | Nat Commun |
|---|---|
| Autors principals: | , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Nature Publishing Group UK
2021
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8241999/ https://ncbi.nlm.nih.gov/pubmed/34188055 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-24317-z |
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