Structure and mechanism of human PrimPol, a DNA polymerase with primase activity

PrimPol is a novel human enzyme that contains both DNA primase and DNA polymerase activities. We present the first structure of human PrimPol in ternary complex with a DNA template-primer and an incoming deoxynucleoside triphosphate (dNTP). The ability of PrimPol to function as a DNA primase stems f...

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Detaylı Bibliyografya
Yayımlandı:Sci Adv
Asıl Yazarlar: Rechkoblit, Olga, Gupta, Yogesh K., Malik, Radhika, Rajashankar, Kanagalaghatta R., Johnson, Robert E., Prakash, Louise, Prakash, Satya, Aggarwal, Aneel K.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Association for the Advancement of Science 2016
Konular:
Research Articles
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5088642/
https://ncbi.nlm.nih.gov/pubmed/27819052
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.1601317
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