PrimPol, an Archaic Primase/Polymerase Operating in Human Cells

We describe a second primase in human cells, PrimPol, which has the ability to start DNA chains with deoxynucleotides unlike regular primases, which use exclusively ribonucleotides. Moreover, PrimPol is also a DNA polymerase tailored to bypass the most common oxidative lesions in DNA, such as abasic...

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Hauptverfasser: García-Gómez, Sara, Reyes, Aurelio, Martínez-Jiménez, María I., Chocrón, E. Sandra, Mourón, Silvana, Terrados, Gloria, Powell, Christopher, Salido, Eduardo, Méndez, Juan, Holt, Ian J., Blanco, Luis
Format: Artigo
Sprache:Inglês
Veröffentlicht: Cell Press 2013
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3899013/
https://ncbi.nlm.nih.gov/pubmed/24207056
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2013.09.025
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