A novel lipid prodrug strategy for sustained delivery of hexadecyloxypropyl 9-[2-(phosphonomethoxy)ethyl]guanine (HDP-PMEG) on unwanted ocular proliferation

Proliferative vitreoretinopathy (PVR) is a blinding eye disease and there is no effective pharmacological measure to prevent PVR development. The difficulty comes from lack of potent antiproliferative agent and lack of sustained delivery to cover high-risk time window for PVR to develop. Lipid prodr...

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Bibliographic Details
Published in:Drug Deliv
Main Authors: Chen, Mei, Hou, Jiangping, Tan, Guilin, Xie, Peng, Freeman, William R., Beadle, James R., Hostetler, Karl Y., Cheng, Lingyun
Format: Artigo
Language:Inglês
Published: Taylor & Francis 2017
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8241053/
https://ncbi.nlm.nih.gov/pubmed/29115885
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/10717544.2017.1399303
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