A novel cytarabine crystalline lipid prodrug: Hexadecyloxypropyl cytarabine 3′,5′-cyclic monophosphate for proliferative vitreoretinopathy

PURPOSE: The objectives of this study were to synthesize and characterize two types of cytarabine (Ara-C) lipid produgs and evaluate the prodrugs for sustained intraocular delivery after administration by intravitreal injection. METHODS: Hexadecyloxypropyl cytarabine 5′-monophosphate (HDP-P-Ara-C) a...

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Main Authors: Kim, Jae Suk, Beadle, James R., Freeman, William R., Hostetler, Karl Y., Hartmann, Kathrin, Valiaeva, Nadejda, Kozak, Igor, Conner, Laura, Trahan, Julissa, Aldern, Kathy A., Cheng, Lingyun
Format: Artigo
Sprog:Inglês
Udgivet: Molecular Vision 2012
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3413433/
https://ncbi.nlm.nih.gov/pubmed/22876115
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