Developmental partitioning of SYK and ZAP70 prevents autoimmunity and cancer

Even though SYK and ZAP70 kinases share high sequence homology and serve analogous functions, their expression in B- and T-cells is strictly segregated throughout evolution. Here, we identified aberrant ZAP70-expression as a common feature in a broad range of B-cell malignancies. We validated SYK as...

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Pubblicato in:Mol Cell
Autori principali: Sadras, Teresa, Martin, Mickaël, Kume, Kohei, Robinson, Mark E., Saravanakumar, Supraja, Lenz, Gal, Chen, Zhengshan, Song, Joo Y., Siddiqi, Tanya, Oksa, Laura, Knapp, Anne Marie, Cutler, Jevon, Cosgun, Kadriye Nehir, Klemm, Lars, Ecker, Veronika, Winchester, Janet, Ghergus, Dana, Soulas-Sprauel, Pauline, Kiefer, Friedemann, Heisterkamp, Nora, Pandey, Akhilesh, Ngo, Vu, Wang, Lili, Jumaa, Hassan, Buchner, Maike, Ruland, Jürgen, Chan, Wing-Chung, Meffre, Eric, Martin, Thierry, Müschen, Markus
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2021
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8239336/
https://ncbi.nlm.nih.gov/pubmed/33878293
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2021.03.043
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