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Zap70 Inhibits Syk-mediated Osteoclast Function

The αvβ3 integrin stimulates the resorptive capacity of the differentiated osteoclast (OC) by organizing its cytoskeleton via the tyrosine kinase, Syk. Thus, Syk-deficient OCs fail to spread or form actin rings, in vitro and in vivo. The Syk family of tyrosine kinases consists of Syk itself and Zap7...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Zou, Wei, Croke, Monica, Fukunaga, Tomohiro, Broekelmann, Thomas J., Mecham, Robert P., Teitelbaum, Steven L.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: 2013
विषय:
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC3977572/
https://ncbi.nlm.nih.gov/pubmed/23494777
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcb.24531
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