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Zap70 Inhibits Syk-mediated Osteoclast Function
The αvβ3 integrin stimulates the resorptive capacity of the differentiated osteoclast (OC) by organizing its cytoskeleton via the tyrosine kinase, Syk. Thus, Syk-deficient OCs fail to spread or form actin rings, in vitro and in vivo. The Syk family of tyrosine kinases consists of Syk itself and Zap7...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2013
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3977572/ https://ncbi.nlm.nih.gov/pubmed/23494777 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcb.24531 |
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