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Cytoskeletal dysfunction dominates in DAP12-deficient osteoclasts
Despite evidence that DAP12 regulates osteoclasts, mice lacking the ITAM-bearing protein exhibit only mild osteopetrosis. Alternatively, Dap12(−/−) mice, also lacking FcRγ, are severely osteopetrotic, suggesting that FcRγ compensates for DAP12 deficiency in the bone-resorbing polykaryons. Controvers...
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| Главные авторы: | , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Company of Biologists
2010
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2923570/ https://ncbi.nlm.nih.gov/pubmed/20720152 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.069872 |
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