Cytoskeletal dysfunction dominates in DAP12-deficient osteoclasts

Despite evidence that DAP12 regulates osteoclasts, mice lacking the ITAM-bearing protein exhibit only mild osteopetrosis. Alternatively, Dap12(−/−) mice, also lacking FcRγ, are severely osteopetrotic, suggesting that FcRγ compensates for DAP12 deficiency in the bone-resorbing polykaryons. Controvers...

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Bibliografiske detaljer
Main Authors: Zou, Wei, Zhu, Tingting, Craft, Clarissa S., Broekelmann, Thomas J., Mecham, Robert P., Teitelbaum, Steven L.
Format: Artigo
Sprog:Inglês
Udgivet: Company of Biologists 2010
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2923570/
https://ncbi.nlm.nih.gov/pubmed/20720152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.069872
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