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DAP12 Couples c-Fms Activation to the Osteoclast Cytoskeleton by Recruitment of Syk
We examined the mechanism by which M-CSF regulates the cytoskeleton and function of the osteoclast, the exclusive bone resorptive cell. We show that binding of M-CSF to its receptor c-Fms generates a signaling complex comprising phosphorylated DAP12, an adaptor containing an immunoreceptor tyrosine-...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2584874/ https://ncbi.nlm.nih.gov/pubmed/18691974 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2008.06.023 |
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