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Syk, c-Src, the αvβ3 integrin, and ITAM immunoreceptors, in concert, regulate osteoclastic bone resorption
In this study, we establish that the tyrosine kinase Syk is essential for osteoclast function in vitro and in vivo. Syk(−/−) osteoclasts fail to organize their cytoskeleton, and, as such, their bone-resorptive capacity is arrested. This defect results in increased skeletal mass in Syk(−/−) embryos a...
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| Auteurs principaux: | , , , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
The Rockefeller University Press
2007
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2064061/ https://ncbi.nlm.nih.gov/pubmed/17353363 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200611083 |
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