Src kinase activation by direct interaction with the integrin β cytoplasmic domain

Src tyrosine kinases transmit integrin-dependent signals pivotal for cell movement and proliferation. Here, we establish a mechanism for Src activation by integrins. c-Src is shown to bind constitutively and selectively to β3 integrins through an interaction involving the c-Src SH3 domain and the ca...

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Bibliographic Details
Main Authors: Arias-Salgado, Elena G., Lizano, Sergio, Sarkar, Sugata, Brugge, Joan S., Ginsberg, Mark H., Shattil, Sanford J.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2003
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC263791/
https://ncbi.nlm.nih.gov/pubmed/14593208
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2336149100
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