Src kinase activation by direct interaction with the integrin β cytoplasmic domain
Src tyrosine kinases transmit integrin-dependent signals pivotal for cell movement and proliferation. Here, we establish a mechanism for Src activation by integrins. c-Src is shown to bind constitutively and selectively to β3 integrins through an interaction involving the c-Src SH3 domain and the ca...
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| Publicat a: | Proc Natl Acad Sci U S A |
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| Autors principals: | , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
2003
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC263791/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14593208/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.2336149100 |
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