Differential Requirements for Src-Family Kinases in SYK or ZAP70-Mediated SLP-76 Phosphorylation in Lymphocytes

In a synthetic biology approach using Schneider (S2) cells, we show that SLP-76 is directly phosphorylated at tyrosines Y113 and Y128 by SYK in the presence of ITAM-containing adapters such as CD3ζ, DAP12, or FcεRγ. This phosphorylation was dependent on at least one functional ITAM and a functional...

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Udgivet i:Front Immunol
Main Authors: Fasbender, Frank, Claus, Maren, Wingert, Sabine, Sandusky, Mina, Watzl, Carsten
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2017
Fag:
Immunology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5500614/
https://ncbi.nlm.nih.gov/pubmed/28736554
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2017.00789
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