Signaling of the ITK (Interleukin 2-inducible T Cell Kinase)-SYK (Spleen Tyrosine Kinase) Fusion Kinase Is Dependent on Adapter SLP-76 and on the Adapter Function of the Kinases SYK and ZAP70

The inducible T cell kinase-spleen tyrosine kinase (ITK-SYK) oncogene consists of the Tec homology-pleckstrin homology domain of ITK and the kinase domain of SYK, and it is believed to be the cause of peripheral T cell lymphoma. We and others have recently demonstrated that this fusion protein is co...

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Main Authors: Hussain, Alamdar, Mohammad, Dara K., Gustafsson, Manuela O., Uslu, Merve, Hamasy, Abdulrahman, Nore, Beston F., Mohamed, Abdalla J., Smith, C. I. Edvard
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2013
Teme:
Cell Biology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3591642/
https://ncbi.nlm.nih.gov/pubmed/23293025
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.374967
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