Ex Vivo Expanded Donor Alloreactive Regulatory T Cells Lose Immunoregulatory, Proliferation and Anti-Apoptotic Markers After Infusion Into ATG-Lymphodepleted, Nonhuman Primate Heart Allograft Recipients

BACKGROUND: Regulatory T cell (Treg) therapy is a promising approach to amelioration of allograft rejection and promotion of organ transplant tolerance. However, the fate of infused Treg, and how this relates to their therapeutic efficacy using different immunosuppressive regimens is poorly understo...

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Veröffentlicht in:Transplantation
Hauptverfasser: Ezzelarab, Mohamed B., Zhang, Hong, Sasaki, Kazuki, Lu, Lien, Zahorchak, Alan F., van der Windt, Dirk J., Dai, Helong, Perez-Gutierrez, Angelica, Bhama, Jay K., Thomson, Angus W.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2021
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8239063/
https://ncbi.nlm.nih.gov/pubmed/33587433
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/TP.0000000000003617
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