Long-term tolerance of islet allografts in nonhuman primates induced by apoptotic donor leukocytes

Immune tolerance to allografts has been pursued for decades as an important goal in transplantation. Administration of apoptotic donor splenocytes effectively induces antigen-specific tolerance to allografts in murine studies. Here we show that two peritransplant infusions of apoptotic donor leukocy...

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Pubblicato in:Nat Commun
Autori principali: Singh, Amar, Ramachandran, Sabarinathan, Graham, Melanie L., Daneshmandi, Saeed, Heller, David, Suarez-Pinzon, Wilma Lucia, Balamurugan, Appakalai N., Ansite, Jeffrey D., Wilhelm, Joshua J., Yang, Amy, Zhang, Ying, Palani, Nagendra P., Abrahante, Juan E., Burlak, Christopher, Miller, Stephen D., Luo, Xunrong, Hering, Bernhard J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6677762/
https://ncbi.nlm.nih.gov/pubmed/31375697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-11338-y
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