Impact of Human Mutant TGFβ1/Fc Protein on Memory and Regulatory T Cell Homeostasis Following Lymphodepletion in Nonhuman Primates

Transforming growth factor β1 (TGFβ1) plays a key role in T cell homeostasis and peripheral tolerance. We evaluated the influence of a novel human mutant TGFβ1/Fc protein on memory CD4(+) and CD8(+) Tcell (Tmem) responses in vitro and their recovery following anti-thymocyte globulin (ATG)-mediated l...

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Publicado no:Am J Transplant
Main Authors: Guo, H., Lu, L., Wang, R., Perez-Gutierrez, A., Abdulkerim, H.S., Zahorchak, A.F., Sumpter, T.L., Reimann, K. A., Thomson, A.W., Ezzelarab, M.B.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5121100/
https://ncbi.nlm.nih.gov/pubmed/27217298
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/ajt.13883
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