Investigation of an ALDH1A1-specific inhibitor for suppression of weight gain in a diet induced mouse model of obesity

BACKGROUND: Retinoic acid (RA) controls diverse physiological functions including weight regulation and energy metabolism. It has been reported that mice lacking ALDH1A1, one of the aldehyde dehydrogenases (ALDH) that synthesize RA, are healthy and resistant to weight gain, raising the possibility t...

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Veröffentlicht in:Int J Obes (Lond)
Hauptverfasser: Haenisch, Michael, Ngyuen, Tai, Fihn, Conrad A., Goldstein, Alex S., Amory, John K., Treuting, Piper, Brabb, Thea, Paik, Jisun
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2021
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8238815/
https://ncbi.nlm.nih.gov/pubmed/33934107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41366-021-00818-1
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