Pharmacological inhibition of ALDH1A enzymes suppresses weight gain in a mouse model of diet-induced obesity

Retinoic acid (RA) is known to play a role in weight regulation. Because mice without ALDH1A1, a major RA synthesizing enzyme, are resistant to diet-induced obesity, we tested a hypothesis that pharmacological inhibition of RA synthesis can suppress weight gain in a murine model of diet-induced obes...

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Udgivet i:Obes Res Clin Pract
Main Authors: Haenisch, Michael, Treuting, Piper M., Brabb, Thea, Goldstein, Alex S., Berkseth, Kathryn, Amory, John K., Paik, Jisun
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5816716/
https://ncbi.nlm.nih.gov/pubmed/28919001
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.orcp.2017.08.003
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