Protective Effects of ALDH1A Enzyme Inhibition on Helicobacter-Induced Colitis in Smad3(−/−) Mice are Associated with Altered α4ß7 Integrin Expression on Activated T Cells

Many inflammatory bowel disease (IBD) patients require surgical intervention due to limited pharmacological treatment options. Antibodies targeting α4ß7, a gut-homing integrin, are one of the most promising IBD treatments. As retinoic acid (RA) regulates expression of gut-homing proteins including α...

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Detaylı Bibliyografya
Yayımlandı:Nutrients
Asıl Yazarlar: Seamons, Audrey, Haenisch, Michael, Meeker, Stacey, Pershutkina, Olesya, Brabb, Thea, Treuting, Piper M., Paik, Jisun
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: MDPI 2020
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7599670/
https://ncbi.nlm.nih.gov/pubmed/32987910
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/nu12102927
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