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Comprehensive Breast Cancer Risk Assessment for CHEK2 and ATM Pathogenic Variant Carriers Incorporating a Polygenic Risk Score and the Tyrer-Cuzick Model

PURPOSE: Breast cancer risks for CHEK2 and ATM pathogenic variant (PV) carriers are modified by an 86-single nucleotide polymorphism polygenic risk score (PRS) and individual clinical factors. Here, we describe comprehensive risk prediction models for women of European ancestry combining PV status,...

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書誌詳細
出版年:JCO Precis Oncol
主要な著者: Gallagher, Shannon, Hughes, Elisha, Kurian, Allison W., Domchek, Susan M., Garber, Judy, Probst, Braden, Morris, Brian, Tshiaba, Placede, Meek, Stephanie, Rosenthal, Eric, Roa, Benjamin, Slavin, Thomas P., Wagner, Susanne, Weitzel, Jeffrey, Gutin, Alexander, Lanchbury, Jerry S., Robson, Mark
フォーマット: Artigo
言語:Inglês
出版事項: Wolters Kluwer Health 2021
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC8238281/
https://ncbi.nlm.nih.gov/pubmed/34322652
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/PO.20.00484
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