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Comprehensive Breast Cancer Risk Assessment for CHEK2 and ATM Pathogenic Variant Carriers Incorporating a Polygenic Risk Score and the Tyrer-Cuzick Model

PURPOSE: Breast cancer risks for CHEK2 and ATM pathogenic variant (PV) carriers are modified by an 86-single nucleotide polymorphism polygenic risk score (PRS) and individual clinical factors. Here, we describe comprehensive risk prediction models for women of European ancestry combining PV status,...

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Detaylı Bibliyografya
Yayımlandı:JCO Precis Oncol
Asıl Yazarlar: Gallagher, Shannon, Hughes, Elisha, Kurian, Allison W., Domchek, Susan M., Garber, Judy, Probst, Braden, Morris, Brian, Tshiaba, Placede, Meek, Stephanie, Rosenthal, Eric, Roa, Benjamin, Slavin, Thomas P., Wagner, Susanne, Weitzel, Jeffrey, Gutin, Alexander, Lanchbury, Jerry S., Robson, Mark
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Wolters Kluwer Health 2021
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC8238281/
https://ncbi.nlm.nih.gov/pubmed/34322652
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/PO.20.00484
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