Development and Validation of a Clinical Polygenic Risk Score to Predict Breast Cancer Risk

PURPOSE: Women with a family history of breast cancer are frequently referred for hereditary cancer genetic testing, yet < 10% are found to have pathogenic variants in known breast cancer susceptibility genes. Large-scale genotyping studies have identified common variants (primarily single-nucleo...

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書目詳細資料
發表在:JCO Precis Oncol
Main Authors: Hughes, Elisha, Tshiaba, Placede, Gallagher, Shannon, Wagner, Susanne, Judkins, Thaddeus, Roa, Benjamin, Rosenthal, Eric, Domchek, Susan, Garber, Judy, Lancaster, Johnathan, Weitzel, Jeffrey, Kurian, Allison W., Lanchbury, Jerry S., Gutin, Alexander, Robson, Mark
格式: Artigo
語言:Inglês
出版: American Society of Clinical Oncology 2020
主題:
Original Reports
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7446363/
https://ncbi.nlm.nih.gov/pubmed/32923876
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/PO.19.00360
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