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Germline pathogenic variants in the Ataxia Telangiectasia Mutated (ATM) gene are associated with high and moderate risks for multiple cancers

Pathogenic variants (PVs) in ATM are relatively common, but the scope and magnitude of risk remains uncertain. This study aimed to estimate ATM PV cancer risks independent of family cancer history. This analysis included patients referred for hereditary cancer testing with a multi-gene panel (N=627,...

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Bibliografiset tiedot
Julkaisussa:Cancer Prev Res (Phila)
Päätekijät: Hall, Michael J, Bernhisel, Ryan, Hughes, Elisha, Larson, Katie, Rosenthal, Eric T., Singh, Nanda A., Lancaster, Johnathan M., Kurian, Allison W
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2021
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC8026745/
https://ncbi.nlm.nih.gov/pubmed/33509806
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1940-6207.CAPR-20-0448
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