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Engineering cellular metabolite transport for biosynthesis of computationally predicted tropane alkaloid derivatives in yeast

Microbial biosynthesis of plant natural products (PNPs) can facilitate access to valuable medicinal compounds and derivatives. Such efforts are challenged by metabolite transport limitations, which arise when complex plant pathways distributed across organelles and tissues are reconstructed in unice...

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Bibliografische gegevens
Gepubliceerd in:Proc Natl Acad Sci U S A
Hoofdauteurs: Srinivasan, Prashanth, Smolke, Christina D.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Academy of Sciences 2021
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8237673/
https://ncbi.nlm.nih.gov/pubmed/34140414
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2104460118
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