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Engineering cellular metabolite transport for biosynthesis of computationally predicted tropane alkaloid derivatives in yeast

Microbial biosynthesis of plant natural products (PNPs) can facilitate access to valuable medicinal compounds and derivatives. Such efforts are challenged by metabolite transport limitations, which arise when complex plant pathways distributed across organelles and tissues are reconstructed in unice...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Srinivasan, Prashanth, Smolke, Christina D.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8237673/
https://ncbi.nlm.nih.gov/pubmed/34140414
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2104460118
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