TAK1 inhibition elicits mitochondrial ROS to block intracellular bacterial colonization

Mitogen-activated protein kinase kinase kinase 7 (MAP3K7), known as TAK1, is an intracellular signaling intermediate of inflammatory responses. However, a series of mouse Tak1 gene deletion analyses have revealed that ablation of TAK1 does not prevent but rather elicits inflammation, which is accomp...

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Bibliografiska uppgifter
I publikationen:Proc Natl Acad Sci U S A
Huvudupphovsmän: López-Pérez, Wilfred, Sai, Kazuhito, Sakamachi, Yosuke, Parsons, Cameron, Kathariou, Sophia, Ninomiya-Tsuji, Jun
Materialtyp: Artigo
Språk:Inglês
Publicerad: National Academy of Sciences 2021
Ämnen:
Biological Sciences
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC8237594/
https://ncbi.nlm.nih.gov/pubmed/34161265
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2023647118
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