TAK1 regulates resident macrophages by protecting lysosomal integrity

Hematopoietic cell survival and death is critical for development of a functional immune system. Here, we report that a protein kinase, TAK1, is selectively required for resident macrophage integrity during embryogenesis. Hematopoietic lineage-specific deletion of Tak1 gene (Tak1(HKO)) caused accumu...

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Dettagli Bibliografici
Pubblicato in:Cell Death Dis
Autori principali: Sakamachi, Yosuke, Morioka, Sho, Mihaly, September R, Takaesu, Giichi, Foley, Julie F, Fessler, Michael B, Ninomiya-Tsuji, Jun
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2017
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5386472/
https://ncbi.nlm.nih.gov/pubmed/28182011
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2017.23
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