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TAK1 regulates resident macrophages by protecting lysosomal integrity
Hematopoietic cell survival and death is critical for development of a functional immune system. Here, we report that a protein kinase, TAK1, is selectively required for resident macrophage integrity during embryogenesis. Hematopoietic lineage-specific deletion of Tak1 gene (Tak1(HKO)) caused accumu...
Gespeichert in:
| Veröffentlicht in: | Cell Death Dis |
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| Hauptverfasser: | , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Nature Publishing Group
2017
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5386472/ https://ncbi.nlm.nih.gov/pubmed/28182011 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2017.23 |
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