Uncialamycin-based antibody–drug conjugates: Unique enediyne ADCs exhibiting bystander killing effect

Antibody–drug conjugates (ADCs) have emerged as valuable targeted anticancer therapeutics with at least 11 approved therapies and over 80 advancing through clinical trials. Enediyne DNA-damaging payloads represented by the flagship of this family of antitumor agents, N-acetyl calicheamicin [Formula:...

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Bibliografski detalji
Izdano u:Proc Natl Acad Sci U S A
Glavni autori: Nicolaou, K. C., Rigol, Stephan, Pitsinos, Emmanuel N., Das, Dipendu, Lu, Yong, Rout, Subhrajit, Schammel, Alexander W., Holte, Dane, Lin, Baiwei, Gu, Christine, Sarvaiya, Hetal, Trinidad, Jose, Barbour, Nicole, Valdiosera, Amanda M., Sandoval, Joseph, Lee, Christina, Aujay, Monette, Fernando, Hanan, Dhar, Anukriti, Karsunky, Holger, Taylor, Nicole, Pysz, Marybeth, Gavrilyuk, Julia
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2021
Teme:
Physical Sciences
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8237573/
https://ncbi.nlm.nih.gov/pubmed/34155147
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2107042118
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