Uncialamycin-based antibody–drug conjugates: Unique enediyne ADCs exhibiting bystander killing effect

Antibody–drug conjugates (ADCs) have emerged as valuable targeted anticancer therapeutics with at least 11 approved therapies and over 80 advancing through clinical trials. Enediyne DNA-damaging payloads represented by the flagship of this family of antitumor agents, N-acetyl calicheamicin [Formula:...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Nicolaou, K. C., Rigol, Stephan, Pitsinos, Emmanuel N., Das, Dipendu, Lu, Yong, Rout, Subhrajit, Schammel, Alexander W., Holte, Dane, Lin, Baiwei, Gu, Christine, Sarvaiya, Hetal, Trinidad, Jose, Barbour, Nicole, Valdiosera, Amanda M., Sandoval, Joseph, Lee, Christina, Aujay, Monette, Fernando, Hanan, Dhar, Anukriti, Karsunky, Holger, Taylor, Nicole, Pysz, Marybeth, Gavrilyuk, Julia
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2021
Assuntos:
Physical Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8237573/
https://ncbi.nlm.nih.gov/pubmed/34155147
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2107042118
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