Submerged fermentation of Streptomyces uncialis providing a biotechnology platform for uncialamycin biosynthesis, engineering, and production

Uncialamycin (UCM) belongs to the anthraquinone-fused subfamily of 10-membered enediyne natural products that exhibits an extraordinary cytotoxicity against a wide spectrum of human cancer cell lines. Antibody-drug conjugates, utilizing synthetic analogues of UCM as payloads, are in preclinical deve...

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Bibliographic Details
Published in:J Ind Microbiol Biotechnol
Main Authors: Hindra, Yang, Dong, Luo, Jun, Huang, Tingting, Yan, Xiaohui, Adhikari, Ajeeth, Teijaro, Christiana N, Ge, Huiming, Shen, Ben
Format: Artigo
Language:Inglês
Published: Oxford University Press 2021
Subjects:
Natural Products
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8210685/
https://ncbi.nlm.nih.gov/pubmed/33739406
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jimb/kuab025
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