Submerged fermentation of Streptomyces uncialis providing a biotechnology platform for uncialamycin biosynthesis, engineering, and production

Uncialamycin (UCM) belongs to the anthraquinone-fused subfamily of 10-membered enediyne natural products that exhibits an extraordinary cytotoxicity against a wide spectrum of human cancer cell lines. Antibody-drug conjugates, utilizing synthetic analogues of UCM as payloads, are in preclinical deve...

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Dettagli Bibliografici
Pubblicato in:J Ind Microbiol Biotechnol
Autori principali: Hindra, Yang, Dong, Luo, Jun, Huang, Tingting, Yan, Xiaohui, Adhikari, Ajeeth, Teijaro, Christiana N, Ge, Huiming, Shen, Ben
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2021
Soggetti:
Natural Products
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8210685/
https://ncbi.nlm.nih.gov/pubmed/33739406
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jimb/kuab025
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