The Role of Notch3 Signaling in Cancer Stemness and Chemoresistance: Molecular Mechanisms and Targeting Strategies

Aberrant Notch signaling profoundly affects cancer progression. Especially the Notch3 receptor was found to be dysregulated in cancer, where its expression is correlated with worse clinicopathological features and poor prognosis. The activation of Notch3 signaling is closely related to the activatio...

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Veröffentlicht in:Front Mol Biosci
Hauptverfasser: Xiu, Mengxi, Wang, Yongbo, Li, Baoli, Wang, Xifeng, Xiao, Fan, Chen, Shoulin, Zhang, Lieliang, Zhou, Bin, Hua, Fuzhou
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2021
Schlagworte:
Molecular Biosciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8237348/
https://ncbi.nlm.nih.gov/pubmed/34195229
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmolb.2021.694141
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