WASp Is Crucial for the Unique Architecture of the Immunological Synapse in Germinal Center B-Cells

B-cells undergo somatic hypermutation and affinity maturation in germinal centers. Somatic hypermutated germinal center B-cells (GCBs) compete to engage with and capture antigens on follicular dendritic cells. Recent studies show that when encountering membrane antigens, GCBs generate actin-rich pod...

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Bibliographic Details
Published in:Front Cell Dev Biol
Main Authors: Li, Yanan, Bhanja, Anshuman, Upadhyaya, Arpita, Zhao, Xiaodong, Song, Wenxia
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2021
Subjects:
Cell and Developmental Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8236648/
https://ncbi.nlm.nih.gov/pubmed/34195186
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcell.2021.646077
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