The CRBN, CUL4A and DDB1 Expression Predicts the Response to Immunomodulatory Drugs and Survival of Multiple Myeloma Patients

Immunomodulatory drugs (IMiDs) are effective in the treatment of multiple myeloma (MM), myelodysplastic syndrome with deletion of chromosome 5q and other haematological malignancies. Recent studies showed that IMiDs bind to cereblon (CRBN), a substrate receptor of the CRL4–CRBN complex, to induce th...

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Publicat a:J Clin Med
Autors principals: Barankiewicz, Joanna, Szumera-Ciećkiewicz, Anna, Salomon-Perzyński, Aleksander, Wieszczy, Paulina, Malenda, Agata, Garbicz, Filip, Prochorec-Sobieszek, Monika, Misiewicz-Krzemińska, Irena, Juszczyński, Przemysław, Lech-Marańda, Ewa
Format: Artigo
Idioma:Inglês
Publicat: MDPI 2021
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8235391/
https://ncbi.nlm.nih.gov/pubmed/34207079
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/jcm10122683
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