Cardiac myosin-binding protein C interaction with actin is inhibited by compounds identified in a high-throughput fluorescence lifetime screen

Cardiac myosin-binding protein C (cMyBP-C) interacts with actin and myosin to modulate cardiac muscle contractility. These interactions are disfavored by cMyBP-C phosphorylation. Heart failure patients often display decreased cMyBP-C phosphorylation, and phosphorylation in model systems has been sho...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Bunch, Thomas A., Guhathakurta, Piyali, Lepak, Victoria C., Thompson, Andrew R., Kanassatega, Rhye-Samuel, Wilson, Anna, Thomas, David D., Colson, Brett A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2021
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8233204/
https://ncbi.nlm.nih.gov/pubmed/34052227
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100840
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