Single-molecule FRET imaging of GPCR dimers in living cells

Class C G protein-coupled receptors (GPCRs) are known to form stable homodimers or heterodimers critical for function, but the oligomeric status of class A and B receptors, which constitute >90% of all GPCRs, remains hotly debated. Single-molecule fluorescence resonance energy transfer (smFRET) i...

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Vydáno v:Nat Methods
Hlavní autoři: Asher, Wesley B., Geggier, Peter, Holsey, Michael D., Gilmore, Grant T., Pati, Avik K., Meszaros, Jozsef, Terry, Daniel S., Mathiasen, Signe, Kaliszewski, Megan J., McCauley, Mitchell D., Govindaraju, Alekhya, Zhou, Zhou, Harikumar, Kaleeckal G., Jaqaman, Khuloud, Miller, Laurence J., Smith, Adam W., Blanchard, Scott C., Javitch, Jonathan A.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2021
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8232828/
https://ncbi.nlm.nih.gov/pubmed/33686301
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41592-021-01081-y
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