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In Vivo–to–In Vitro Extrapolation of Transporter-Mediated Renal Clearance: Relative Expression Factor Versus Relative Activity Factor Approach
About 30% of approved drugs are cleared predominantly by renal clearance (CL(r)). Of these, many are secreted by transporters. For these drugs, in vitro–to–in vivo extrapolation of transporter-mediated renal secretory clearance (CL(sec,plasma)) is important to prospectively predict their renal clear...
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| Publicado no: | Drug Metab Dispos |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The American Society for Pharmacology and Experimental
Therapeutics
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8232064/ https://ncbi.nlm.nih.gov/pubmed/33824168 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.121.000367 |
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